A Role for PCNA Ubiquitination in Immunoglobulin Hypermutation

Proliferating cell nuclear antigen (PCNA) is a DNA polymerase cofactor and regulator of replication-linked functions. Upon DNA damage, yeast and vertebrate PCNA is modified at the conserved lysine K164 by ubiquitin, which mediates error-prone replication across lesions via translesion polymerases. W...

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Detalhes bibliográficos
Main Authors: Arakawa, Hiroshi, Moldovan, George-Lucian, Saribasak, Huseyin, Saribasak, Nesibe Nur, Jentsch, Stefan, Buerstedde, Jean-Marie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618868/
https://ncbi.nlm.nih.gov/pubmed/17105346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0040366
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