L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia

by Wang, Qian, Holst, Jeff
Published in Am J Cancer Res (2015)

Changes in CpG methylation marks differentiation of human myeloid progenitors to neutrophils

by Wong, Justin J.L., Holst, Jeff
Published in Stem Cell Investig (2014)

Protein Phosphatases 1 and 2A Transiently Associate with Myosin during the Peak Rate of Secretion from Mast Cells

by Holst, Jeff, Sim, Alistair T.R., Ludowyke, Russell I.
Published 2002

Luciferase expression and bioluminescence does not affect tumor cell growth in vitro or in vivo

by Tiffen, Jessamy C, Bailey, Charles G, Ng, Cynthia, Rasko, John EJ, Holst, Jeff
Published 2010

The role of serine/threonine protein phosphatases in exocytosis.

by Sim, Alistair T R, Baldwin, Monique L, Rostas, John A P, Holst, Jeff, Ludowyke, Russell I
Published 2003

Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2

by Garibsingh, Rachel-Ann A., Otte, Nicholas J., Ndaru, Elias, Colas, Claire, Grewer, Christof, Holst, Jeff, Schlessinger, Avner
Published in Front Chem (2018)

EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer

by Zhang, Blake K., Moran, Anne M., Bailey, Charles G., Rasko, John E. J., Holst, Jeff, Wang, Qian
Published in Cell Commun Signal (2019)

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells

by Bröer, Angelika, Gauthier-Coles, Gregory, Rahimi, Farid, van Geldermalsen, Michelle, Dorsch, Dieter, Wegener, Ansgar, Holst, Jeff, Bröer, Stefan
Published in J Biol Chem (2019)

Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening

by Colas, Claire, Grewer, Christof, Otte, Nicholas James, Gameiro, Armanda, Albers, Thomas, Singh, Kurnvir, Shere, Helen, Bonomi, Massimiliano, Holst, Jeff, Schlessinger, Avner
Published in PLoS Comput Biol (2015)

Identifying microRNA determinants of human myelopoiesis

by Rajasekhar, Megha, Schmitz, Ulf, Flamant, Stephane, Wong, Justin J.-L., Bailey, Charles G., Ritchie, William, Holst, Jeff, Rasko, John E. J.
Published in Sci Rep (2018)

Impaired Nutrient Signaling and Body Weight Control in a Na(+) Neutral Amino Acid Cotransporter (Slc6a19)-deficient Mouse

by Bröer, Angelika, Juelich, Torsten, Vanslambrouck, Jessica M., Tietze, Nadine, Solomon, Peter S., Holst, Jeff, Bailey, Charles G., Rasko, John E. J., Bröer, Stefan
Published 2011

Identification of nuclear-enriched miRNAs during mouse granulopoiesis

by Wong, Justin JL, Ritchie, William, Gao, Dadi, Lau, Katherine A, Gonzalez, Maria, Choudhary, Anupma, Taft, Ryan J, Rasko, John EJ, Holst, Jeff
Published 2014

Micro-RNA response to imatinib mesylate in patients with chronic myeloid leukemia

by Flamant, Stéphane, Ritchie, William, Guilhot, Joëlle, Holst, Jeff, Bonnet, Marie-Laure, Chomel, Jean-Claude, Guilhot, François, Turhan, Ali G., Rasko, John E.J.
Published 2010

The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo

by Guan, Fiona H. X., Bailey, Charles G., Metierre, Cynthia, O’Young, Patrick, Gao, Dadi, Khoo, Teh Liane, Holst, Jeff, Rasko, John E. J.
Published in J Hematol Oncol (2017)

Inhibition of glutamine uptake regulates mTORC1, glutamine metabolism and cell growth in prostate cancer

by Wang, Qian, Hardie, Rae-Anne, Balaban, Seher, Schreuder, Mark, Hoy, Andrew, van Geldermalsen, Michelle, Fazli, Ladan, Nagarajah, Rajini, Bailey, Charles, Rasko, John, Holst, Jeff
Published 2014

Benzylserine inhibits breast cancer cell growth by disrupting intracellular amino acid homeostasis and triggering amino acid response pathways

by van Geldermalsen, Michelle, Quek, Lake-Ee, Turner, Nigel, Freidman, Natasha, Pang, Angel, Guan, Yi Fang, Krycer, James R., Ryan, Renae, Wang, Qian, Holst, Jeff
Published in BMC Cancer (2018)

Targeting of cytosolic phospholipase A(2)α impedes cell cycle re-entry of quiescent prostate cancer cells

by Yao, Mu, Xie, Chanlu, Kiang, Mei-Yee, Teng, Ying, Harman, David, Tiffen, Jessamy, Wang, Qian, Sved, Paul, Bao, Shisan, Witting, Paul, Holst, Jeff, Dong, Qihan
Published in Oncotarget (2015)

SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation

by Thientosapol, Eddy Sanchai, Bosnjak, Daniel, Durack, Timothy, Stevanovski, Igor, van Geldermalsen, Michelle, Holst, Jeff, Jahan, Zeenat, Shepard, Caitlin, Weninger, Wolfgang, Kim, Baek, Brink, Robert, Jolly, Christopher J.
Published in Proc Natl Acad Sci U S A (2018)

Heritable expansion of the genetic code in mouse and zebrafish

by Chen, Yuting, Ma, Ji, Lu, Wenqing, Tian, Meilin, Thauvin, Marion, Yuan, Chonggang, Volovitch, Michel, Wang, Qian, Holst, Jeff, Liu, Mingyao, Vriz, Sophie, Ye, Shixin, Wang, Lei, Li, Dali
Published in Cell Res (2017)

Androgen receptor and nutrient signaling pathways coordinate increased amino acid transport in prostate cancer progression

by Wang, Qian, Bailey, Charles G, Ng, Cynthia, Tiffen, Jessamy, Thoeng, Annora, Minnas, Vineet, Lehman, Melanie L, Hendy, Stephen C, Buchanan, Grant, Nelson, Colleen C, Rasko, John EJ, Holst, Jeff
Published 2012