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Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2

The Alanine-Serine-Cysteine transporter (SLC1A5, ASCT2), is a neutral amino acid exchanger involved in the intracellular homeostasis of amino acids in peripheral tissues. Given its role in supplying glutamine to rapidly proliferating cancer cells in several tumor types such as triple-negative breast...

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Détails bibliographiques
Publié dans:Front Chem
Auteurs principaux: Garibsingh, Rachel-Ann A., Otte, Nicholas J., Ndaru, Elias, Colas, Claire, Grewer, Christof, Holst, Jeff, Schlessinger, Avner
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066518/
https://ncbi.nlm.nih.gov/pubmed/30137742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00279
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