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SAMHD1 enhances immunoglobulin hypermutation by promoting transversion mutation
Activation-induced deaminase (AID) initiates hypermutation of Ig genes in activated B cells by converting C:G into U:G base pairs. G(1)-phase variants of uracil base excision repair (BER) and mismatch repair (MMR) then deploy translesion polymerases including REV1 and Pol η, which exacerbates mutati...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5948975/ https://ncbi.nlm.nih.gov/pubmed/29669924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1719771115 |
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