High‐Throughput Kinetic Analysis for Target‐Directed Covalent Ligand Discovery

Cysteine‐reactive small molecules are used as chemical probes of biological systems and as medicines. Identifying high‐quality covalent ligands requires comprehensive kinetic analysis to distinguish selective binders from pan‐reactive compounds. Quantitative irreversible tethering (qIT), a general m...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Craven, Gregory B., Affron, Dominic P., Allen, Charlotte E., Matthies, Stefan, Greener, Joe G., Morgan, Rhodri M. L., Tate, Edward W., Armstrong, Alan, Mann, David J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947712/
https://ncbi.nlm.nih.gov/pubmed/29480525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201711825
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