Multiparameter Kinetic Analysis for Covalent Fragment Optimization by Using Quantitative Irreversible Tethering (qIT)

Chemical probes that covalently modify cysteine residues in a protein‐specific manner are valuable tools for biological investigations. Covalent fragments are increasingly implemented as probe starting points, but the complex relationship between fragment structure and binding kinetics makes covalen...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Craven, Gregory B., Affron, Dominic P., Kösel, Teresa, Wong, Tsz Lam M., Jukes, Zoë H., Liu, Chun‐Ting, Morgan, Rhodri M. L., Armstrong, Alan, Mann, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754465/
https://ncbi.nlm.nih.gov/pubmed/32659037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000457
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