A carregar...
A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases
[Image: see text] A novel fragment-based drug discovery approach is reported which irreversibly tethers drug-like fragments to catalytic cysteines. We attached an electrophile to 100 fragments without significant alterations in the reactivity of the electrophile. A mass spectrometry assay discovered...
Na minha lista:
| Main Authors: | , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4113264/ https://ncbi.nlm.nih.gov/pubmed/24870364 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500345q |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|