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Quantitative Irreversible Tethering (qIT) for Target-directed Covalent Fragment Screening
Small molecules that react to form covalent bonds with proteins are widely used as biological tools and therapeutic agents. Screening cysteine-reactive fragments against a protein target is an efficient way to identify chemical starting points for covalent probe development. Mass spectrometry is oft...
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| Veröffentlicht in: | Bio Protoc |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Bio-Protocol
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7842680/ https://ncbi.nlm.nih.gov/pubmed/33659502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21769/BioProtoc.3855 |
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