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Vinyl sulfonamide synthesis for irreversible tethering via a novel α-selenoether protection strategy
Vinyl sulfonamides are valuable electrophiles for targeted protein modification and inhibition. We describe a novel approach to the synthesis of terminal vinyl sulfonamides which uses mild oxidative conditions to induce elimination of an α-selenoether masking group. The method complements traditiona...
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| Publicado no: | Medchemcomm |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6349062/ https://ncbi.nlm.nih.gov/pubmed/30774862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00566d |
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