High‐Throughput Kinetic Analysis for Target‐Directed Covalent Ligand Discovery

Cysteine‐reactive small molecules are used as chemical probes of biological systems and as medicines. Identifying high‐quality covalent ligands requires comprehensive kinetic analysis to distinguish selective binders from pan‐reactive compounds. Quantitative irreversible tethering (qIT), a general m...

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Enregistré dans:
Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: Craven, Gregory B., Affron, Dominic P., Allen, Charlotte E., Matthies, Stefan, Greener, Joe G., Morgan, Rhodri M. L., Tate, Edward W., Armstrong, Alan, Mann, David J.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5947712/
https://ncbi.nlm.nih.gov/pubmed/29480525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201711825
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