Mapping Interactions with the Chaperone Network Reveals Factors that Protect Against Tau Aggregation

A network of molecular chaperones is known to bind proteins (“clients”) and balance their folding, function and turnover. However, it is often not clear which chaperones are critical for selective recognition of individual clients. It is also not clear why these key chaperones might fail in protein...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Mok, Sue-Ann, Condello, Carlo, Freilich, Rebecca, Gillies, Anne, Arhar, Taylor, Oroz, Javier, Kadavath, Harindranath, Julien, Olivier, Assimon, Victoria A., Rauch, Jennifer N., Dunyak, Bryan M., Lee, Jungsoon, Tsai, Francis T.F., Wilson, Mark R., Zweckstetter, Markus, Dickey, Chad A., Gestwicki, Jason E.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5942583/
https://ncbi.nlm.nih.gov/pubmed/29728653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0057-1
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