Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

Anti–vascular endothelial growth factor (VEGF) therapy has failed to improve survival in patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy include the up-regulation of alternative angiogenic and proinflammatory factors. Obesity is associated with hypoxic adipo...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Sci Transl Med
Asıl Yazarlar: Incio, Joao, Ligibel, Jennifer A., McManus, Daniel T., Suboj, Priya, Jung, Keehoon, Kawaguchi, Kosuke, Pinter, Matthias, Babykutty, Suboj, Chin, Shan M., Vardam, Trupti D., Huang, Yuhui, Rahbari, Nuh N., Roberge, Sylvie, Wang, Dannie, Gomes-Santos, Igor L., Puchner, Stefan B., Schlett, Christopher L., Hoffmman, Udo, Ancukiewicz, Marek, Tolaney, Sara M., Krop, Ian E., Duda, Dan G., Boucher, Yves, Fukumura, Dai, Jain, Rakesh K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936748/
https://ncbi.nlm.nih.gov/pubmed/29540614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag0945
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