Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

Anti–vascular endothelial growth factor (VEGF) therapy has failed to improve survival in patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy include the up-regulation of alternative angiogenic and proinflammatory factors. Obesity is associated with hypoxic adipo...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Sci Transl Med
Autores principales: Incio, Joao, Ligibel, Jennifer A., McManus, Daniel T., Suboj, Priya, Jung, Keehoon, Kawaguchi, Kosuke, Pinter, Matthias, Babykutty, Suboj, Chin, Shan M., Vardam, Trupti D., Huang, Yuhui, Rahbari, Nuh N., Roberge, Sylvie, Wang, Dannie, Gomes-Santos, Igor L., Puchner, Stefan B., Schlett, Christopher L., Hoffmman, Udo, Ancukiewicz, Marek, Tolaney, Sara M., Krop, Ian E., Duda, Dan G., Boucher, Yves, Fukumura, Dai, Jain, Rakesh K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936748/
https://ncbi.nlm.nih.gov/pubmed/29540614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag0945
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares