Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with a dismal prognosis for most patients. Fibrosis and inflammation are hallmarks of tumor desmoplasia. We have previously demonstrated that preventing the activation of pancreatic stellate cells (PSCs) and alleviati...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Incio, Joao, Suboj, Priya, Chin, Shan M., Vardam-Kaur, Trupti, Liu, Hao, Hato, Tai, Babykutty, Suboj, Chen, Ivy, Deshpande, Vikram, Jain, Rakesh K., Fukumura, Dai
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671732/
https://ncbi.nlm.nih.gov/pubmed/26641266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141392
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