Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with a dismal prognosis for most patients. Fibrosis and inflammation are hallmarks of tumor desmoplasia. We have previously demonstrated that preventing the activation of pancreatic stellate cells (PSCs) and alleviati...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Incio, Joao, Suboj, Priya, Chin, Shan M., Vardam-Kaur, Trupti, Liu, Hao, Hato, Tai, Babykutty, Suboj, Chen, Ivy, Deshpande, Vikram, Jain, Rakesh K., Fukumura, Dai
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4671732/
https://ncbi.nlm.nih.gov/pubmed/26641266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141392
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