Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

Anti–vascular endothelial growth factor (VEGF) therapy has failed to improve survival in patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy include the up-regulation of alternative angiogenic and proinflammatory factors. Obesity is associated with hypoxic adipo...

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Publicado no:Sci Transl Med
Main Authors: Incio, Joao, Ligibel, Jennifer A., McManus, Daniel T., Suboj, Priya, Jung, Keehoon, Kawaguchi, Kosuke, Pinter, Matthias, Babykutty, Suboj, Chin, Shan M., Vardam, Trupti D., Huang, Yuhui, Rahbari, Nuh N., Roberge, Sylvie, Wang, Dannie, Gomes-Santos, Igor L., Puchner, Stefan B., Schlett, Christopher L., Hoffmman, Udo, Ancukiewicz, Marek, Tolaney, Sara M., Krop, Ian E., Duda, Dan G., Boucher, Yves, Fukumura, Dai, Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936748/
https://ncbi.nlm.nih.gov/pubmed/29540614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag0945
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