Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

The survival benefit of anti–vascular endothelial growth factor (VEGF) therapy in metastatic colorectal cancer (mCRC) patients is limited to a few months because of acquired resistance. We show that anti-VEGF therapy induced remodeling of the extracellular matrix with subsequent alteration of the ph...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Transl Med
मुख्य लेखकों: Rahbari, Nuh N., Kedrin, Dmitriy, Incio, Joao, Liu, Hao, Ho, William W., Nia, Hadi T., Edrich, Christina M., Jung, Keehoon, Daubriac, Julien, Chen, Ivy, Heishi, Takahiro, Martin, John D., Huang, Yuhui, Maimon, Nir, Reissfelder, Christoph, Weitz, Jurgen, Boucher, Yves, Clark, Jeffrey W., Grodzinsky, Alan J., Duda, Dan G., Jain, Rakesh K., Fukumura, Dai
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2016
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457741/
https://ncbi.nlm.nih.gov/pubmed/27733559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf5219
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