Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

The survival benefit of anti–vascular endothelial growth factor (VEGF) therapy in metastatic colorectal cancer (mCRC) patients is limited to a few months because of acquired resistance. We show that anti-VEGF therapy induced remodeling of the extracellular matrix with subsequent alteration of the ph...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Rahbari, Nuh N., Kedrin, Dmitriy, Incio, Joao, Liu, Hao, Ho, William W., Nia, Hadi T., Edrich, Christina M., Jung, Keehoon, Daubriac, Julien, Chen, Ivy, Heishi, Takahiro, Martin, John D., Huang, Yuhui, Maimon, Nir, Reissfelder, Christoph, Weitz, Jurgen, Boucher, Yves, Clark, Jeffrey W., Grodzinsky, Alan J., Duda, Dan G., Jain, Rakesh K., Fukumura, Dai
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457741/
https://ncbi.nlm.nih.gov/pubmed/27733559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf5219
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados