Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer

Antiangiogenic therapy with antibodies against VEGF (bevacizumab) or VEGFR2 (ramucirumab) has been proven efficacious in colorectal cancer (CRC) patients. However, the improvement in overall survival is modest and only in combination with chemotherapy. Thus, there is an urgent need to identify poten...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Jung, Keehoon, Heishi, Takahiro, Incio, Joao, Huang, Yuhui, Beech, Elizabeth Y., Pinter, Matthias, Ho, William W., Kawaguchi, Kosuke, Rahbari, Nuh N., Chung, Euiheon, Kim, Jun Ki, Clark, Jeffrey W., Willett, Christopher G., Yun, Seok Hyun, Luster, Andrew D., Padera, Timothy P., Jain, Rakesh K., Fukumura, Dai
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625928/
https://ncbi.nlm.nih.gov/pubmed/28900008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710754114
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