Targeting CXCR4-dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer

Antiangiogenic therapy with antibodies against VEGF (bevacizumab) or VEGFR2 (ramucirumab) has been proven efficacious in colorectal cancer (CRC) patients. However, the improvement in overall survival is modest and only in combination with chemotherapy. Thus, there is an urgent need to identify poten...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Jung, Keehoon, Heishi, Takahiro, Incio, Joao, Huang, Yuhui, Beech, Elizabeth Y., Pinter, Matthias, Ho, William W., Kawaguchi, Kosuke, Rahbari, Nuh N., Chung, Euiheon, Kim, Jun Ki, Clark, Jeffrey W., Willett, Christopher G., Yun, Seok Hyun, Luster, Andrew D., Padera, Timothy P., Jain, Rakesh K., Fukumura, Dai
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625928/
https://ncbi.nlm.nih.gov/pubmed/28900008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710754114
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