Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

The survival benefit of anti–vascular endothelial growth factor (VEGF) therapy in metastatic colorectal cancer (mCRC) patients is limited to a few months because of acquired resistance. We show that anti-VEGF therapy induced remodeling of the extracellular matrix with subsequent alteration of the ph...

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Publicado en:Sci Transl Med
Main Authors: Rahbari, Nuh N., Kedrin, Dmitriy, Incio, Joao, Liu, Hao, Ho, William W., Nia, Hadi T., Edrich, Christina M., Jung, Keehoon, Daubriac, Julien, Chen, Ivy, Heishi, Takahiro, Martin, John D., Huang, Yuhui, Maimon, Nir, Reissfelder, Christoph, Weitz, Jurgen, Boucher, Yves, Clark, Jeffrey W., Grodzinsky, Alan J., Duda, Dan G., Jain, Rakesh K., Fukumura, Dai
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457741/
https://ncbi.nlm.nih.gov/pubmed/27733559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf5219
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