Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

Anti–vascular endothelial growth factor (VEGF) therapy has failed to improve survival in patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy include the up-regulation of alternative angiogenic and proinflammatory factors. Obesity is associated with hypoxic adipo...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Incio, Joao, Ligibel, Jennifer A., McManus, Daniel T., Suboj, Priya, Jung, Keehoon, Kawaguchi, Kosuke, Pinter, Matthias, Babykutty, Suboj, Chin, Shan M., Vardam, Trupti D., Huang, Yuhui, Rahbari, Nuh N., Roberge, Sylvie, Wang, Dannie, Gomes-Santos, Igor L., Puchner, Stefan B., Schlett, Christopher L., Hoffmman, Udo, Ancukiewicz, Marek, Tolaney, Sara M., Krop, Ian E., Duda, Dan G., Boucher, Yves, Fukumura, Dai, Jain, Rakesh K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936748/
https://ncbi.nlm.nih.gov/pubmed/29540614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aag0945
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