PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity

PURPOSE: Obesity promotes pancreatic and breast cancer progression via mechanisms that are poorly understood. Although obesity is associated with increased systemic levels of placental growth factor (PlGF), the role of PlGF in obesity-induced tumor progression is not known. PlGF and its receptor vas...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Incio, Joao, Tam, Joshua, Rahbari, Nuh N., Suboj, Priya, McManus, Daniel T., Chin, Shan M., Vardam, Trupti D., Batista, Ana, Babykutty, Suboj, Jung, Keehoon, Khachatryan, Anna, Hato, Tai, Ligibel, Jennifer, Krop, Ian E., Puchner, Stefan B., Schlett, Christopher L., Hoffmman, Udo, Ancukiewicz, Marek, Shibuya, Masabumi, Carmeliet, Peter, Soares, Raquel, Duda, Dan G., Jain, Rakesh K., Fukumura, Dai
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911258/
https://ncbi.nlm.nih.gov/pubmed/26861455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1839
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