PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity

PURPOSE: Obesity promotes pancreatic and breast cancer progression via mechanisms that are poorly understood. Although obesity is associated with increased systemic levels of placental growth factor (PlGF), the role of PlGF in obesity-induced tumor progression is not known. PlGF and its receptor vas...

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Publicado no:Clin Cancer Res
Main Authors: Incio, Joao, Tam, Joshua, Rahbari, Nuh N., Suboj, Priya, McManus, Daniel T., Chin, Shan M., Vardam, Trupti D., Batista, Ana, Babykutty, Suboj, Jung, Keehoon, Khachatryan, Anna, Hato, Tai, Ligibel, Jennifer, Krop, Ian E., Puchner, Stefan B., Schlett, Christopher L., Hoffmman, Udo, Ancukiewicz, Marek, Shibuya, Masabumi, Carmeliet, Peter, Soares, Raquel, Duda, Dan G., Jain, Rakesh K., Fukumura, Dai
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911258/
https://ncbi.nlm.nih.gov/pubmed/26861455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1839
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