PlGF/VEGFR-1 signaling promotes macrophage polarization and accelerated tumor progression in obesity

PURPOSE: Obesity promotes pancreatic and breast cancer progression via mechanisms that are poorly understood. Although obesity is associated with increased systemic levels of placental growth factor (PlGF), the role of PlGF in obesity-induced tumor progression is not known. PlGF and its receptor vas...

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Published in:Clin Cancer Res
Main Authors: Incio, Joao, Tam, Joshua, Rahbari, Nuh N., Suboj, Priya, McManus, Daniel T., Chin, Shan M., Vardam, Trupti D., Batista, Ana, Babykutty, Suboj, Jung, Keehoon, Khachatryan, Anna, Hato, Tai, Ligibel, Jennifer, Krop, Ian E., Puchner, Stefan B., Schlett, Christopher L., Hoffmman, Udo, Ancukiewicz, Marek, Shibuya, Masabumi, Carmeliet, Peter, Soares, Raquel, Duda, Dan G., Jain, Rakesh K., Fukumura, Dai
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911258/
https://ncbi.nlm.nih.gov/pubmed/26861455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1839
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