Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1

Telomeric repeat binding factor 1 (TRF1) is essential to the maintenance of telomere chromatin structure and integrity. However, how telomere integrity is maintained, especially in response to damage, remains poorly understood. Here, we identify Nek7, a member of the Never in Mitosis Gene A (NIMA) k...

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Vydáno v:Mol Cell
Hlavní autoři: Tan, Rong, Nakajima, Satoshi, Wang, Qun, Sun, Hongxiang, Xue, Jing, Wu, Jian, Hellwig, Sabine, Zeng, Xuemei, Yates, Nathan A., Smithgall, Thomas E., Lei, Ming, Jiang, Yu, Levine, Arthur S., Su, Bing, Lan, Li
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924698/
https://ncbi.nlm.nih.gov/pubmed/28216227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.01.015
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