Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death

Cellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telomere. Both oxidative stress and telomere shortening/dysfunction cause aging-related degenerative pathologies and increase cancer risk. However, a direct connection between oxidative damage to telomeric...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Sun, Luxi, Tan, Rong, Xu, Jianquan, LaFace, Justin, Gao, Ying, Xiao, Yanchun, Attar, Myriam, Neumann, Carola, Li, Guo-Min, Su, Bing, Liu, Yang, Nakajima, Satoshi, Levine, Arthur S., Lan, Li
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513870/
https://ncbi.nlm.nih.gov/pubmed/26082495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv598
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