In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are needed. Here we use a pooled in vivo genetic screening approach using CRISPR–Cas9 genome editing in transplantable tumours in mice treated with imm...

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Veröffentlicht in:Nature
Hauptverfasser: Manguso, Robert T., Pope, Hans W., Zimmer, Margaret D., Brown, Flavian D., Yates, Kathleen B., Miller, Brian C., Collins, Natalie B., Bi, Kevin, LaFleur, Martin W., Juneja, Vikram R., Weiss, Sarah A., Lo, Jennifer, Fisher, David E., Miao, Diana, Van Allen, Eliezer, Root, David E., Sharpe, Arlene H., Doench, John G., Haining, W. Nicholas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924693/
https://ncbi.nlm.nih.gov/pubmed/28723893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature23270
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