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PTPN2 regulates the generation of exhausted CD8(+) T cell subpopulations and restrains tumor immunity
CD8(+) T cell exhaustion is a state of dysfunction acquired in chronic viral infection and cancer, characterized by the formation of Slamf6(+) progenitor exhausted and Tim-3(+) terminally exhausted subpopulations through unknown mechanisms. Here we establish the phosphatase PTPN2 as a novel regulato...
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| Publicado no: | Nat Immunol |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6754306/ https://ncbi.nlm.nih.gov/pubmed/31527834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0480-4 |
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