PTPN2 regulates the generation of exhausted CD8(+) T cell subpopulations and restrains tumor immunity

CD8(+) T cell exhaustion is a state of dysfunction acquired in chronic viral infection and cancer, characterized by the formation of Slamf6(+) progenitor exhausted and Tim-3(+) terminally exhausted subpopulations through unknown mechanisms. Here we establish the phosphatase PTPN2 as a novel regulato...

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Udgivet i:Nat Immunol
Main Authors: LaFleur, Martin W., Nguyen, Thao H., Coxe, Matthew A., Miller, Brian C., Yates, Kathleen B., Gillis, Jacob E., Sen, Debattama R., Gaudiano, Emily F., Abosy, Rose Al, Freeman, Gordon J., Haining, W. Nicholas, Sharpe, Arlene H.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6754306/
https://ncbi.nlm.nih.gov/pubmed/31527834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0480-4
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