A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

Therapies that target the function of immune cells have significant clinical efficacy in diseases such as cancer and autoimmunity. Although functional genomics has accelerated therapeutic target discovery in cancer, its use in primary immune cells is limited because vector delivery is inefficient an...

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Publicado no:Nat Commun
Main Authors: LaFleur, Martin W., Nguyen, Thao H., Coxe, Matthew A., Yates, Kathleen B., Trombley, Justin D., Weiss, Sarah A., Brown, Flavian D., Gillis, Jacob E., Coxe, Daniel J., Doench, John G., Haining, W. Nicholas, Sharpe, Arlene H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6458184/
https://ncbi.nlm.nih.gov/pubmed/30971695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09656-2
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