Chronic β2AR stimulation limits CFTR activation in human airway epithelia

Traditional pulmonary therapies for cystic fibrosis (CF) target the downstream effects of CF transmembrane conductance regulator (CFTR) dysfunction (the cause of CF). Use of one such therapy, β-adrenergic bronchodilators (such as albuterol), is nearly universal for airway clearance. Conversely, nove...

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Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Brewington, John J., Backstrom, Jessica, Feldman, Amanda, Kramer, Elizabeth L., Moncivaiz, Jessica D., Ostmann, Alicia J., Zhu, Xiaoting, Lu, L. Jason, Clancy, John P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916247/
https://ncbi.nlm.nih.gov/pubmed/29467332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93029
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