Clinically approved CFTR modulators rescue Nrf2 dysfunction in cystic fibrosis airway epithelia

Cystic fibrosis (CF) is a multiorgan progressive genetic disease caused by loss of functional cystic fibrosis transmembrane conductance regulator (CFTR) channel. Previously, we identified a significant dysfunction in CF cells and model mice of the transcription factor nuclear factor E2–related facto...

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Pubblicato in:J Clin Invest
Autori principali: Borcherding, Dana C., Siefert, Matthew E., Lin, Songbai, Brewington, John, Sadek, Hesham, Clancy, John P., Plafker, Scott M., Ziady, Assem G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6668689/
https://ncbi.nlm.nih.gov/pubmed/31145101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96273
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