Chronic β2AR stimulation limits CFTR activation in human airway epithelia

Traditional pulmonary therapies for cystic fibrosis (CF) target the downstream effects of CF transmembrane conductance regulator (CFTR) dysfunction (the cause of CF). Use of one such therapy, β-adrenergic bronchodilators (such as albuterol), is nearly universal for airway clearance. Conversely, nove...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Brewington, John J., Backstrom, Jessica, Feldman, Amanda, Kramer, Elizabeth L., Moncivaiz, Jessica D., Ostmann, Alicia J., Zhu, Xiaoting, Lu, L. Jason, Clancy, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916247/
https://ncbi.nlm.nih.gov/pubmed/29467332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93029
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