Detection of CFTR function and modulation in primary human nasal cell spheroids

BACKGROUND: Expansion of CFTR modulators to patients with rare/undescribed mutations will be facilitated by patient-derived models quantifying CFTR function and restoration. We aimed to generate a personalized model system of CFTR function and modulation using non-surgically obtained nasal epithelia...

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Publicat a:J Cyst Fibros
Autors principals: Brewington, John J., Filbrandt, Erin T., LaRosa, F.J., Ostmann, Alicia J., Strecker, Lauren M., Szczesniak, Rhonda D., Clancy, John P.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868354/
https://ncbi.nlm.nih.gov/pubmed/28712885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcf.2017.06.010
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