Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus

Amylin phosphorylates ERK (p-ERK) in the area postrema to reduce eating and synergizes with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) hypothalamic nuclei to reduce food intake and body weight. The current studies assessed potential amylin and amylin-leptin ARC/VMN int...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Diabetes
Prif Awduron: Lutz, Thomas A., Coester, Bernd, Whiting, Lynda, Dunn-Meynell, Ambrose A., Boyle, Christina N., Bouret, Sebastien G., Levin, Barry E., Le Foll, Christelle
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Diabetes Association 2018
Pynciau:
Metabolism
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910000/
https://ncbi.nlm.nih.gov/pubmed/29467172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1347
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