Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat

Selectively bred diet-induced obese (DIO) rats become obese on a high-fat diet and are leptin resistant before becoming obese. Compared with diet-resistant (DR) neonates, DIO neonates have impaired leptin-dependent arcuate (ARC) neuropeptide Y/agouti-related peptide (NPY/AgRP) and α-melanocyte-stimu...

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Опубликовано в: :Am J Physiol Regul Integr Comp Physiol
Главные авторы: Johnson, Miranda D., Bouret, Sebastien G., Dunn-Meynell, Ambrose A., Boyle, Christina N., Lutz, Thomas A., Levin, Barry E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2016
Предметы:
Obesity, Diabetes and Energy Homeostasis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256974/
https://ncbi.nlm.nih.gov/pubmed/27629888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00326.2016
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