IL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic nucleus neurons

Rats selectively bred to develop diet-induced obesity (DIO) have an early onset reduction in the sensitivity of their ventromedial hypothalamic nucleus (VMN) neurons to leptin compared with diet-resistant (DR) rats. This reduced sensitivity includes decreased leptin receptor (Lepr-b) mRNA expression...

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Udgivet i:Am J Physiol Regul Integr Comp Physiol
Main Authors: Larsen, Louise, Le Foll, Christelle, Dunn-Meynell, Ambrose A., Levin, Barry E.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2016
Fag:
Obesity, Diabetes and Energy Homeostasis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142158/
https://ncbi.nlm.nih.gov/pubmed/27534878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00258.2016
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