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IL-6 ameliorates defective leptin sensitivity in DIO ventromedial hypothalamic nucleus neurons
Rats selectively bred to develop diet-induced obesity (DIO) have an early onset reduction in the sensitivity of their ventromedial hypothalamic nucleus (VMN) neurons to leptin compared with diet-resistant (DR) rats. This reduced sensitivity includes decreased leptin receptor (Lepr-b) mRNA expression...
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| Publicado no: | Am J Physiol Regul Integr Comp Physiol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5142158/ https://ncbi.nlm.nih.gov/pubmed/27534878 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00258.2016 |
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