Implications of intercorrelation between hepatic CYP3A4‐CYP2C8 enzymes for the evaluation of drug–drug interactions: a case study with repaglinide

AIMS: Statistically significant positive correlations are reported for the abundance of hepatic drug‐metabolizing enzymes. We investigate, as an example, the impact of CYP3A4–CYP2C8 intercorrelation on the predicted interindividual variabilities of clearance and drug–drug interactions (DDIs) for rep...

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Bibliografiska uppgifter
I publikationen:Br J Clin Pharmacol
Huvudupphovsmän: Doki, Kosuke, Darwich, Adam S., Achour, Brahim, Tornio, Aleksi, Backman, Janne T., Rostami‐Hodjegan, Amin
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2018
Ämnen:
Drug Interactions
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903242/
https://ncbi.nlm.nih.gov/pubmed/29381228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13533
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