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The CYP2C8 inhibitor trimethoprim increases the plasma concentrations of repaglinide in healthy subjects
AIMS: Our aim was to investigate the effect of the CYP2C8 inhibitor trimethoprim on the pharmacokinetics and pharmacodynamics of the antidiabetic drug repaglinide, and to examine the influence of the former on the metabolism of the latter in vitro. METHODS: In a randomized, double-blind, crossover s...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1884466/ https://ncbi.nlm.nih.gov/pubmed/15025742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.02027.x |
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