Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide

BACKGROUND AND AIMS: Gemfibrozil, and particularly its combination with itraconazole, greatly increases the area under the plasma concentration-time curve [AUC(0, ∞)] and response to the cytochrome P450 (CYP) 2C8 and 3A4 substrate repaglinide. In vitro, gemfibrozil is a more potent inhibitor of CYP2...

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Bibliografiske detaljer
Main Authors: Niemi, Mikko, Backman, Janne T, Juntti-Patinen, Laura, Neuvonen, Mikko, Neuvonen, Pertti J
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2005
Fag:
Drug Interactions
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884918/
https://ncbi.nlm.nih.gov/pubmed/16042675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2005.02385.x
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