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Implications of intercorrelation between hepatic CYP3A4‐CYP2C8 enzymes for the evaluation of drug–drug interactions: a case study with repaglinide
AIMS: Statistically significant positive correlations are reported for the abundance of hepatic drug‐metabolizing enzymes. We investigate, as an example, the impact of CYP3A4–CYP2C8 intercorrelation on the predicted interindividual variabilities of clearance and drug–drug interactions (DDIs) for rep...
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| Publicado no: | Br J Clin Pharmacol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5903242/ https://ncbi.nlm.nih.gov/pubmed/29381228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13533 |
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