Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

Fetal hemoglobin (HbF, α(2)γ(2)) level is genetically controlled and modifies severity of adult hemoglobin (HbA, α(2)β(2)) disorders, sickle cell disease and β-thalassemia. Common genetic variation affects expression of BCL11A, a regulator of HbF silencing. To uncover how BCL11A supports the develop...

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Udgivet i:Cell
Main Authors: Liu, Nan, Hargreaves, Victoria V., Zhu, Qian, Kurland, Jesse V., Hong, Jiyoung, Kim, Woojin, Sher, Falak, Macias-Trevino, Claudio, Rogers, Julia M., Kurita, Ryo, Nakamura, Yukio, Yuan, Guo-Cheng, Bauer, Daniel E., Xu, Jian, Bulyk, Martha L., Orkin, Stuart H.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889339/
https://ncbi.nlm.nih.gov/pubmed/29606353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.016
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