Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

Fetal hemoglobin (HbF, α(2)γ(2)) level is genetically controlled and modifies severity of adult hemoglobin (HbA, α(2)β(2)) disorders, sickle cell disease and β-thalassemia. Common genetic variation affects expression of BCL11A, a regulator of HbF silencing. To uncover how BCL11A supports the develop...

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Publicado no:Cell
Main Authors: Liu, Nan, Hargreaves, Victoria V., Zhu, Qian, Kurland, Jesse V., Hong, Jiyoung, Kim, Woojin, Sher, Falak, Macias-Trevino, Claudio, Rogers, Julia M., Kurita, Ryo, Nakamura, Yukio, Yuan, Guo-Cheng, Bauer, Daniel E., Xu, Jian, Bulyk, Martha L., Orkin, Stuart H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889339/
https://ncbi.nlm.nih.gov/pubmed/29606353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.016
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