Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch

Fetal hemoglobin (HbF, α(2)γ(2)) level is genetically controlled and modifies severity of adult hemoglobin (HbA, α(2)β(2)) disorders, sickle cell disease and β-thalassemia. Common genetic variation affects expression of BCL11A, a regulator of HbF silencing. To uncover how BCL11A supports the develop...

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Publié dans:Cell
Auteurs principaux: Liu, Nan, Hargreaves, Victoria V., Zhu, Qian, Kurland, Jesse V., Hong, Jiyoung, Kim, Woojin, Sher, Falak, Macias-Trevino, Claudio, Rogers, Julia M., Kurita, Ryo, Nakamura, Yukio, Yuan, Guo-Cheng, Bauer, Daniel E., Xu, Jian, Bulyk, Martha L., Orkin, Stuart H.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889339/
https://ncbi.nlm.nih.gov/pubmed/29606353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.03.016
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