Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin

Genes encoding human β-type globin undergo a developmental switch from embryonic to fetal to adult-type expression. Mutations in the adult form cause inherited hemoglobinopathies or globin disorders, including sickle cell disease and thalassemia. Some experimental results have suggested that these d...

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Foilsithe in:Science
Main Authors: Masuda, Takeshi, Wang, Xin, Maeda, Manami, Canver, Matthew C., Sher, Falak, Funnell, Alister P. W., Fisher, Chris, Suciu, Maria, Martyn, Gabriella E., Norton, Laura J., Zhu, Catherine, Kurita, Ryo, Nakamura, Yukio, Xu, Jian, Higgs, Douglas R., Crossley, Merlin, Bauer, Daniel E., Orkin, Stuart H., Kharchenko, Peter V., Maeda, Takahiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778394/
https://ncbi.nlm.nih.gov/pubmed/26816381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3312
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