Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

Reactivation of fetal hemoglobin (HbF) in adults ameliorates the severity of the common β-globin disorders. The transcription factor BCL11A is a critical modulator of hemoglobin switching and HbF silencing, yet the molecular mechanism through which BCL11A coordinates the developmental switch is inco...

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Autors principals: Xu, Jian, Bauer, Daniel E., Kerenyi, Marc A., Vo, Thuy D., Hou, Serena, Hsu, Yu-Jung, Yao, Huilan, Trowbridge, Jennifer J., Mandel, Gail, Orkin, Stuart H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3631619/
https://ncbi.nlm.nih.gov/pubmed/23576758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303976110
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