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Regulation of the fetal hemoglobin silencing factor BCL11A

The clinical severity of sickle cell disease and β-thalassemia, the major disorders of β-globin, can be ameliorated by increased production of fetal hemoglobin (HbF). Here, we provide a brief overview of the fetal-to-adult hemoglobin switch that occurs in humans shortly after birth and review our cu...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Ann N Y Acad Sci
Main Authors: Basak, Anindita, Sankaran, Vijay G.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870126/
https://ncbi.nlm.nih.gov/pubmed/26963603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13024
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