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Multivariate Analysis of 2D (1)H,(13)C methyl NMR Spectra of Monoclonal Antibody Therapeutics to Facilitate Assessment of Higher Order Structure
Two-dimensional (2D) (1)H-(13)C methyl NMR provides a powerful tool to probe the higher order structure (HOS) of monoclonal antibodies (mAbs), since spectra can readily be acquired on intact mAbs at natural isotopic abundance, and small changes in chemical environment and structure give rise to obse...
में बचाया:
| में प्रकाशित: | Anal Chem |
|---|---|
| मुख्य लेखकों: | , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886730/ https://ncbi.nlm.nih.gov/pubmed/28937210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b03571 |
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