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Assessment of the Higher Order Structure of Formulated Monoclonal Antibody Therapeutics by 2D Methyl Correlated NMR and Principal Component Analysis.
Characterization of the higher order structure (HOS) of protein therapeutics and in particular, monoclonal antibodies, by 2D (1)H-(13)C methyl correlated NMR has been demonstrated as precise and robust. Such characterization can be greatly enhanced when collections of spectra are analyzed using mult...
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| Publicado en: | Curr Protoc Protein Sci |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8288048/ https://ncbi.nlm.nih.gov/pubmed/32407007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpps.105 |
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