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Multivariate Analysis of 2D (1)H,(13)C methyl NMR Spectra of Monoclonal Antibody Therapeutics to Facilitate Assessment of Higher Order Structure

Two-dimensional (2D) (1)H-(13)C methyl NMR provides a powerful tool to probe the higher order structure (HOS) of monoclonal antibodies (mAbs), since spectra can readily be acquired on intact mAbs at natural isotopic abundance, and small changes in chemical environment and structure give rise to obse...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Anal Chem
Prif Awduron: Arbogast, Luke W., Delaglio, Frank, Schiel, John E., Marino, John P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886730/
https://ncbi.nlm.nih.gov/pubmed/28937210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b03571
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