Comparative Analysis of 1D PROFILE and 2D (1)H,(13)C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies

The use of NMR spectroscopy has emerged as a premier tool to characterize the higher order structure of protein therapeutics and in particular IgG1 monoclonal antibodies (mAbs). Due to their large size, traditional (1)H-(15)N correlation experiments have proven exceedingly difficult to implement on...

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Bibliografske podrobnosti
izdano v:Anal Chem
Main Authors: Elliott, Korth W., Ghasriani, Houman, Wikström, Mats, Giddens, John P., Aubin, Yves, Delaglio, Frank, Marino, John P., Arbogast, Luke W.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054654/
https://ncbi.nlm.nih.gov/pubmed/32267681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b05385
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