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Comparative Analysis of 1D PROFILE and 2D (1)H,(13)C Methyl NMR Methods for Characterization of the Higher Order Structure of IgG1 Monoclonal Antibodies
The use of NMR spectroscopy has emerged as a premier tool to characterize the higher order structure of protein therapeutics and in particular IgG1 monoclonal antibodies (mAbs). Due to their large size, traditional (1)H-(15)N correlation experiments have proven exceedingly difficult to implement on...
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| Опубликовано в: : | Anal Chem |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8054654/ https://ncbi.nlm.nih.gov/pubmed/32267681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.9b05385 |
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