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Multivariate Analysis of 2D (1)H,(13)C methyl NMR Spectra of Monoclonal Antibody Therapeutics to Facilitate Assessment of Higher Order Structure
Two-dimensional (2D) (1)H-(13)C methyl NMR provides a powerful tool to probe the higher order structure (HOS) of monoclonal antibodies (mAbs), since spectra can readily be acquired on intact mAbs at natural isotopic abundance, and small changes in chemical environment and structure give rise to obse...
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| Publicado no: | Anal Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886730/ https://ncbi.nlm.nih.gov/pubmed/28937210 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.7b03571 |
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