Simple NMR methods for evaluating higher order structures of monoclonal antibody therapeutics with quinary structure

Monoclonal antibody (mAb) drugs constitute the largest class of protein therapeutics currently on the market. Correctly folded protein higher order structure (HOS), including quinary structure, is crucial for mAb drug quality. The quinary structure is defined as the association of quaternary structu...

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Veröffentlicht in:J Pharm Biomed Anal
Hauptverfasser: Chen, Kang, Long, Dianna S., Lute, Scott C., Levy, Michaella J., Brorson, Kurt A., Keire, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066182/
https://ncbi.nlm.nih.gov/pubmed/27344629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2016.06.007
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