Application of 2D-NMR with room temperature NMR probes for the assessment of the higher order structure of filgrastim

The higher order structure (HOS) of biotherapeutics is a critical quality attribute that can be evaluated by nuclear magnetic resonance (NMR) spectroscopy at atomic resolution. NMR spectral mapping of HOS can be used to establish HOS consistency of a biologic across manufacturing changes or to compa...

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Detalhes bibliográficos
Publicado no:J Pharm Biomed Anal
Main Authors: Brinson, Robert G., Ghasriani, Houman, Hodgson, Derek J., Adams, Kristie M., McEwen, Ian, Freedberg, Darón I., Chen, Kang, Keire, David A., Aubin, Yves, Marino, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057790/
https://ncbi.nlm.nih.gov/pubmed/28454057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2017.03.063
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