Structural mechanisms of CFTR function and dysfunction

Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) chloride channel plays a critical role in regulating transepithelial movement of water and electrolyte in exocrine tissues. Malfunction of the channel because of mutations of the cftr gene results in CF, the most prevalent lethal geneti...

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Bibliografiske detaljer
Udgivet i:J Gen Physiol
Main Authors: Hwang, Tzyh-Chang, Yeh, Jiunn-Tyng, Zhang, Jingyao, Yu, Ying-Chun, Yeh, Han-I, Destefano, Samantha
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2018
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881446/
https://ncbi.nlm.nih.gov/pubmed/29581173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201711946
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